Steve Allen
- The Pinky And The Brain Reunion Special as Himself
Harry Andronis
- Yes, Always as Engineer
John Astin
- Mice Don't Dance as Grover Whalen
James Belushi
- Das Mouse as McGuire
Jeff Glen Bennett
- Of Mouse And Man as Locke
- Cheese Roll Call as Wensleydale
- Brainania as Allan Fontain Bisque
- TV or Not TV as Kilmer
- A Pinky And The Brain Christmas as Schotzie
- Brain Meets Brawn as Dr. Jekyl
- Plan Brain From Outer Space as Zalgar
- Welcome to the Jungle as Hippie
- A Little Off The Top as Sampson
- Two Mice And A Baby as Baloney
- This Old Mouse as Game Announcer
- Where The Deer And The Mousealopes Play as Chris
- Funny, You Don't Look Rhennish as Jakob
- Say What, Earth? as Castro-type
- All You Need Is Narf as Jim
- The Pinky Protocol as Christopher W.[alken]
- Brain Storm as Kale Mumphausen
- Calvin Brain as Fabrizio Ditzo
- Brain's Way as Tom Caljones
- Briany Jack as Howie
- Brainie The Poo as Jagger
- The Family That Poits Together, Narfs Together as Squeege
- To Russia With Lab Mice as Scientist #2
- Whatever Happened To Baby Brain as Irving Thyroid
- The Pinky And The Brain Reunion Special as Leonard Sheldon
- Brainwashed Part 3: Wash Harder as Dr. Mordough
Julie Bernstein
- Broadway Malady as Female Singer
- Bah, Wilderness as Singer B
- Brainie The Poo as Female Singer
- Hickory Dickory Bonk as Singer #2
Steve Bernstein
- Operation Sea Lion as Singer #2
- Bah, Wilderness as Singer C
- Hickory Dickory Bonk as Singer #3
- A Legendary Tail as Chorus Member #3
Tom Bodett
- Brainwashed Part 1: Brain, Brain, Go Away as Himself
Earl Boen
- A Pinky And The Brain Christmas as Santa
- Hercules Unwound as Zeus
- Say What, Earth? as Earth
Ernest Borgnine
- The Visit as Father
Lisa Bradley
- Puppet Rulers as Neice
Dr. Joyce Brothers
- The Pinky And The Brain Reunion Special as Himself
Julie Brown
- Beach Blanket Brain as Danette Spoonabello
- Star Warners as Minerva Mink
Darren Burrows
- Briany Jack as Crowfeather
Corey Burton
- The Mummy as Cushing
- But, That's Not All Folks! as Technician
- Pinky At The Bat as Van Spoony
- Brainwashed Part 2: I Am Not A Hat as Strawboater
Levar Burton
- The Real Life as Murray
Garielle Carterius
- Bah, Wilderness as Asian Boy
Nancy Cartwright
- In The Garden Of Mindy as Mindy
- Star Warners as Mindy
Larry Cedar
- Napoleon Brainaparte as Jacques
- Fly as Newt
- Mouse Of La Mancha as Rags
- The Third Mouse as The Major
- Collect 'Em All as Johannes Gutenberg
- Brain's Night Off as Chef
- Brainwashed Part 1: Brain, Brain, Go Away as Fedora
Dick Clark
- You'll Never Eat Food Pellets In This Town, Again! as Dick Clark
- The Pinky And The Brain Reunion Special as Himself
Townsend Coleman
- Cinebrania as Hal Slug
- The Pinky Protocol as FBI agent
- You'll Never Eat Food Pellets In This Town, Again! as Bobby Fenster
- Inherit The Wheeze as Les Tarr
- Brain Food as Bryce Wallace
- Brainwashed Part 1: Brain, Brain, Go Away as Bobby Bob Yokel
- Brainwashed Part 2: I Am Not A Hat as Bobby Bob Yokel
- Brainwashed Part 3: Wash Harder as Bobby Bob Yokel
David Coulier
- Brain's Song as Tom H.[anks]
Jim Cummings
- Das Mouse as Admiral
- Pinky & The Fog as The Mist
- Brainania as Fred Floppel
- Mouse Of La Mancha as Innkeeper
- Robin Brain as Chuck
- Brain's Song as V/O #1
- A Little Off The Top as Saran
- Whatever Happened To Baby Brain as Orson W.[elles]
John Cypher
- Bah, Wilderness as Administrator
Barry Dennen
- Pavlov's Mice as Czar
Michael David Donovan
- Brain's Night Off as Maitre D
Dani Douthette
- Brain Storm as Agnes
Richard Doyle
- Around The World In 80 Narfs as Phineas Fogg
Julia Duffy
- A Little Off The Top as Delilah
Nora Dunn
- Brainwashed Part 3: Wash Harder as Precious
Cary Elwes
- Melancholy Brain as Hamlet
- Whatever Happened To Baby Brain as Director
Miriam Flynn
- Leggo My Ego as Woman
Lauri Frasier
- Meet John Brain as Reporter
Brian George
- Around The World In 80 Narfs as Sir Niles
- Fly as Drake
- Pinkasso as Critic #1
Rebecca Gilchrist
- Bah, Wilderness as Camp Supervisor
John Glover
- Pinky's Turn as Tycoon
Chasen Greig
- Puppet Rulers as Nephew
David Alan Grier
- TV or Not TV as Marlon
Pam Grier
- Inherit The Wheeze as Julie Auburn
Jennifer Hale
- Operation Sea Lion as Winny
Mark Hamill
- Brain Acres as Jimmy Jo Jr.
Dorian Harewood
- Mice Don't Dance as Bojangles
Jess Harnell
- Where No Mouse Has Gone Before as Alien Singer
- Spell-Bound as Wakko
- Puppet Rulers as Station Manager
- Ambulatory Abe as Tourist
- All You Need Is Narf as Fred
- Brain's Way as Fred Spinatra
- Star Warners as Wakk Skylicker
Peter Hastings
- Yes, Always as Writer
Pamela Hayden
- The Real Life as Dawn
- Whatever Happened To Baby Brain as Trudy
Phil Hayes
- You'll Never Eat Food Pellets In This Town, Again! as Pollster #2
Charlie Howarton
- The Third Mouse as Cribbage
Olivia Hussey
- Melancholy Brain as Queen
Eric Idle
- The Family That Poits Together, Narfs Together as Mom & Dad
Peter Jason
- Hoop Schemes as Bobby Nacht
Richard Karron
- The Pink Candidate as Sweaty Pete
T'keyah Crystal Keymah
- Inherit The Wheeze as Singer
Charles Kimbrough
- You'll Never Eat Food Pellets In This Town, Again! as Sandy Dreckmore
Clyde Kusatsu
- Big in Japan as Hama
Mauruce LaMarche
- Star Warners as Brain-2-Me-2
Joe Lala
- Napoleon Brainaparte as Francois
Steve Landesberg
- Leggo My Ego as Freud
Richard Libertini
- Napoleon Brainaparte as Talleyrand
Tress MacNeille
- Tokyo Grows as Japanese Girl
- Pinky & The Fog as Woman
- Cheese Roll Call as Brie
- Brainania as Mrs. Applebee
- TV or Not TV as Janet
- Napoleon Brainaparte as Madame De Jambone
- A Pinky And The Brain Christmas as Dave Burl
- Spell-Bound as Dot
- The World Can Wait as Billie
- Puppet Rulers as Kid #1
- Around The World In 80 Narfs as Passerby
- Fly as Janine
- Mouse Of La Mancha as Wench
- The Visit as Mother
- It's Only A Paper World as Marna Strutt
- Pinkasso as Genevieve
- Plan Brain From Outer Space as Sully
- Robin Brain as Old Woman
- The Pink Candidate as Old Woman
- Brain's Song as Katie C.[ouric]
- Welcome to the Jungle as Phyllis
- Megalomaniacs Anonymous as Female Rock Star
- Brain Of The Future as Queen Roach
- Brinky as Rikki L.[ake]
- Two Mice And A Baby as Baby
- Leave It To Beavers as Woman
- Hoop Schemes as Rue McClanahy
- This Old Mouse as Cheerleader
- Where The Deer And The Mousealopes Play as Mousealope Calf
- Brain Noir as Billie
- Funny, You Don't Look Rhennish as Sarah
- Mice Don't Dance as Old Woman
- Brain's Bogie as Cher
- Pinky's Plan as First Lady
- The Pinky Protocol as Mary Hartless
- The Real Life as Eisenhower
- Calvin Brain as Elsa Kitsch
- T.H.E.Y as First Lady
- Brain's Way as Bernie
- Briany Jack as Sticky
- A Pinky And The Brain Halloween as Greta
- Broadway Malady as Thelma
- You Said A Mouseful as Sammy
- You'll Never Eat Food Pellets In This Town, Again! as Billie
- The Family That Poits Together, Narfs Together as Mrs. Perfect
- Inherit The Wheeze as Nicky O'Tine
- Brain Food as Julie Green
- Pinky's Turn as First Lady
- Dangerous Brains as Girl
- A Legendary Tail as Townswoman
- Whatever Happened To Baby Brain as Hooda Hepper
- Brainwashed Part 1: Brain, Brain, Go Away as First Lady
- Brainwashed Part 2: I Am Not A Hat as First Lady
- Brainwashed Part 3: Wash Harder as First Lady
- Star Warners as Princess Dot
John Mariano
- Napoleon Brainaparte as Head Genarme
- Spell-Bound as Bobby
- Where The Deer And The Mousealopes Play as Robert
- Star Warners as Bobby
Garry Marshall
- A Pinky And The Brain Halloween as Mr. Itch
Gail Matthius
- Of Mouse And Man as Gail
- Bubba Bo Bob Brain as Yee Haw Girl
- Brain Drained as Wendy
- The Family That Poits Together, Narfs Together as kathie glee
Roddy McDowall
- Snowball as Snowball
- Welcome to the Jungle as Snowball
- Brain Noir as Snowball
- A Pinky And The Brain Halloween as Snowball
- Brainwashed Part 2: I Am Not A Hat as Snowball
- Brainwashed Part 3: Wash Harder as Snowball
Steve McGowan
- The Pink Candidate as Reporter
Michael McKean
- Robin Brain as Toll Collector
- Brain Drained as Ponytail
- Broadway Malady as Schniederlander
- Inherit The Wheeze as Mel Anoma
Gavin McLeod
- The Pinky And The Brain Reunion Special as Himself
Ed McMahon
- The Pinky And The Brain Reunion Special as Himself
Sam McMurray
- TV or Not TV as Shawn
- Robin Brain as Tax Man #1
- Brain's Bogie as Video Teacher
Jim Meskimem
- The Pink Candidate as Bob D.[ole]
- Where The Deer And The Mousealopes Play as Del Monte
Diane Michelle
- To Russia With Lab Mice as Mousey Galore
Candi Milo
- Beach Blanket Brain as Claire
Brian Stokes Mitchell
- A Legendary Tail as Big Jimmy Fruithead
John Moschitta Jr.
- You Said A Mouseful as Mister Sackey
Pat Musick
- The Maze as Scientist #2
- Bah, Wilderness as Dutch Girl
- You'll Never Eat Food Pellets In This Town, Again! as T.V. Mom
Laraine Newman
- Calvin Brain as Giselle
- But, That's Not All Folks! as Housewife
- Bah, Wilderness as Secretary
Bobbie Page
- Bah, Wilderness as Singer D
Rob Paulsen
- Star Warners as 3-Pinky-O
Tony Pope
- Brain's Night Off as Waiter
Jan Rabson
- Hoop Schemes as Referee
- Brain Noir as Farmer
Clive Revill
- Melancholy Brain as King
John Rhys-Davies
- Brainie The Poo as Narrator
Kevin M. Richardson
- The Pink Candidate as Bernard S.[haw]
- Hoop Schemes as Jelly-Head
Richard Ridgely
- TV or Not TV as Announcer
Bumper Robinson
- Dangerous Brains as Tyrone Spellbinder
Alex Rocco
- Fly as Floyd Nesbit
Andrea Romano
- Yes, Always as Director
- Brainwashed Part 1: Brain, Brain, Go Away as Herself
Roger Rose
- TV or Not TV as David L.[etterman]
- It's Only A Paper World as David L.[etterman]
- Hoop Schemes as Man #1
- Briany Jack as Hippie
- But, That's Not All Folks! as Sportscaster
Neil Ross
- Jockey For Position as Announcer
John Rubano
- You'll Never Eat Food Pellets In This Town, Again! as Jimmy S.[mits]
John Rubinow
- Around The World In 80 Narfs as Gummy Gibberish
- But, That's Not All Folks! as Swat Leader
Luke Ruegger
- Puppet Rulers as Kid #1
Nathan Ruegger
- Star Warners as Skippoda
Tom Ruegger
- Yes, Always as Producer
Paul Rugg
- Puppet Rulers as Uncle Albert
- Megalomaniacs Anonymous as Dr. Belvedere
- This Old Mouse as Mr. Sultana
- My Feldmans, My Friends as Mr. Sultana
- The Pinky And The Brain Reunion Special as Mr. Director
Peter Scolari
- Brain Drained as Weird Guy
- The Family That Poits Together, Narfs Together as Mr. Perfect
Phil Snyder
- The Pink Candidate as Bob C.
Sherri Stoner
- Spell-Bound as Slappy
- Star Warners as Slappy Wanna Nappy
Cree Summer
- Brinky as Bunny
- Brainwashed Part 2: I Am Not A Hat as Receptionist
Jeffrey Tambor
- Of Mouse And Man as Beetle Fiero
Mark L. Taylor
- You'll Never Eat Food Pellets In This Town, Again! as Pollster #1
John Tesh
- A Pinky And The Brain Halloween as Himself
Lauren Tom
- Brain Acres as Shopper
Marcelo Tubert
- Dangerous Brains as Hector Papdopolis
Scott Valentine
- The Real Life as Spike
Chick Vennera
- Spell-Bound as Pesto
- Star Warners as Pesto
John Vernon
- Of Mouse And Man as Punk
Mike Villani
- You Said A Mouseful as Announcer
Frank Welker
- Tokyo Grows as Gollyzilla
- Where No Mouse Has Gone Before as President
- Brainania as The President
- Napoleon Brainaparte as Napoleon
- Snowball as Board Member
- A Pinky And The Brain Christmas as The President
- Spell-Bound as Runt
- Battle for the Planet as Ralph
- Where Rodents Dare as Mr. President
- Brain Meets Brawn as Billy
- Don't Tread On Us as Benjamin Franklin
- Ambulatory Abe as Grandfather
- It's Only A Paper World as Mr. President
- Plan Brain From Outer Space as Odin
- The Pink Candidate as Mr. President
- Brain's Song as Mr. President
- Megalomaniacs Anonymous as Ross P.[erot]
- Brain Of The Future as Mr. President
- Brinky as Bartender
- Leave It To Beavers as Beaver
- Where The Deer And The Mousealopes Play as Fred Floppel
- Brain's Bogie as Fred Floppel
- Pinky's Plan as Mr. President
- Brain Acres as Maurice
- The Pinky Protocol as Fred Floppel
- T.H.E.Y as Mr. President
- But, That's Not All Folks! as General
- Operation Sea Lion as Commander
- Schpiel-borg 2000 as Steven S.[pielberg]
- The Family That Poits Together, Narfs Together as Steven S.
- Pinky's Turn as Mr. President
- A Legendary Tail as Dirt Townsmen
- Brainwashed Part 1: Brain, Brain, Go Away as Mr. President
- Brainwashed Part 2: I Am Not A Hat as Mr. President
- Star Warners as Girth Plotz, Chewbooboo
Billy West
- Hoop Schemes as Marv A.[lbert]
- Pinky & The Brain And... Larry as Larry
- All You Need Is Narf as Indian Man
- The Pinky Protocol as Anthony H.[opkins]
- Pinky Suavo as Regis
- Brain's Way as Dean
- A Pinky And The Brain Halloween as Receptionist
- Broadway Malady as Roger E.[bert]
- Bah, Wilderness as Wilderness Counselor
- Pinky At The Bat as George Beansteiner
- You'll Never Eat Food Pellets In This Town, Again! as Nifty Bizarre
- Beach Blanket Brain as Dodohead
- Pinky's Turn as Mayor
- The Pinky And The Brain Reunion Special as Earl Wendell
Tom Wilson
- Dangerous Brains as Larry Bruhn